How can leptin cause so many problems?

There are three main ways leptin causes problems:

  1. Leptin problems enforce starvation metabolism and slow metabolic rate, resulting in adverse consequences in using energy everywhere in the body, which affects everything in an adverse way.
  2. Low leptin in the brain exposes brain cells to excess damage, resulting specifically in damage to NMDA receptors thus increasing the risk for Parkinson’s disease. It also provokes an inflammatory chain of events in the brain leading to the accumulation of plaques that cause Alzheimer’s disease.
  3. Extra pounds of fat give off excess inflammatory signals that cause all diseases of ageing.